Some bodybuilders use drugs such as anabolic steroids and precursor substances such as prohormones to increase muscle hypertrophy. Anabolic steroids cause hypertrophy of both types (I and II) of muscle fibers, likely caused by an increased synthesis of muscle proteins. They also provoke undesired side effects including hepatotoxicity, gynecomastia, acne, the early onset of male pattern baldness and a decline in the body's own testosterone production, which can cause testicular atrophy.[42][43][44] Other performance-enhancing substances used by competitive bodybuilders include human growth hormone (HGH), which can cause acromegaly.
So when you get to that point in your leg workout where you're completely dead but have to finish an insane drop set, then you need to go to the gun scenario. Would you finish the set if there were a gun pressed against your temple? Hell yes you would, so do the damn set! As an advanced lifter, it's not supposed to be easy or "fun" and you might even puke. Just man up, find your happy place and do your damn set!
Often people make great progress for about the first 3 months and then plateau, usually because their body has become used to the movements and exercises ceasing them from further progression. Your routine should be changed about every 12 weeks (3 months) this keeps you interested at the gym, and constantly shocks your muscles with new exercises which is what will help you continue to grow and improve in the gym.
For example, I had some nagging tendinitis in my brachioradialis (forearm muscle) and doing hammer curls was unbearable. So, I swapped those in for standing alternating dumbbell curls, preacher curls, and standing cambered bar reverse curls with light weight. For shoulders, I have a slight tear in my left shoulder and when it's aggravated, I avoid all pressing movements all together. Focus on side/front laterals and rear delt movements. As for knees, not allowing my knees to come out pass my toes on squats takes the pressure of the part of my knee that gets sore. Also, a few minutes on the Stairmaster Stepmill is a good way to get the knee joint warmed up and ready for work. 
It is quite difficult to achieve competitive success without proper supplementation. For example, you could easily replenish your carbs on an Ironman course with white bread and Fig Newtons, but you'd have to carry a backpack full of the stuff to ensure your calorie intake was adequate. It's much easier to supplement with a carb/sodium replacement gel.
Bodybuilding became more popular in the 1950s and 1960s with the emergence of strength and gymnastics champions, and the simultaneous popularization of bodybuilding magazines, training principles, nutrition for bulking up and cutting down, the use of protein and other food supplements, and the opportunity to enter physique contests. The number of bodybuilding organizations grew, and most notably the International Federation of Bodybuilders (IFBB) was founded in 1946 by Canadian brothers Joe and Ben Weider. Other bodybuilding organizations included the Amateur Athletic Union (AAU), National Amateur Bodybuilding Association (NABBA), and the World Bodybuilding Guild (WBBG). Consequently, the male-dominated contests grew both in number and in size. Besides the many "Mr. XXX" (insert town, city, state, or region) championships, the most prestigious titles[according to whom?] were Mr. America, Mr. World, Mr. Universe, Mr. Galaxy, and ultimately Mr. Olympia, which was started in 1965 by the IFBB and is now considered the most important bodybuilding competition in the world.
Your legs are even more important if you play sports. Strong legs will help you run faster, become stronger, and most importantly, lower your chance of being injured. I know this first hand. I used to train my legs sparingly because the workouts were so hard. I simply didn't feel like going to the gym on leg days and even if I did, I would just go through the motions and never train at a high enough intensity.
There are so many different supplement companies out there with so many different products. Magazines advertise countless products and are endorsed by numerous massive bodybuilders. Maybe the supplements work, maybe they don't. Let's just focus on the essentials that are proven time and time again by people like you and me and spare your wallet in the meantime.
Now, I understand that going from two to three meals a day to six can be quite a shock. However, I do not expect you to change everything all at once. As a matter of fact, this is the reason why 99% of dieters out there fail. My goal is to have you succeed just as I did when I had weight problems. Therefore, if you rather ease into this program slowly by making small changes to your current diet on a bi-weekly basis, then please visit my article on Easing Into A Bodybuilding Diet
A good pair of legs is as important to the body as a good set of wheels is to a car. But like a quality set of wheels, strong, healthy legs come at a high price. So, don’t take the following powerful legs exercises — especially the sissy squat—lightly. Because this is an incredibly intense workout that will turn your thighs into killer wheels. Serious focus and intensity are required.
I've been training for 20 years and to commemorate that long training slog, I sat down and compiled my 10 best training tips. After I wrote them down, though, I realized that while they'd no doubt be valuable to the novice trainee, they're probably things that the advanced trainee already knows. So I also compiled a second list to augment the first. The second list gives my best advanced tips. The end result is, I hope, something that's valuable to both levels of trainees.
Intensive weight training causes micro-tears to the muscles being trained; this is generally known as microtrauma. These micro-tears in the muscle contribute to the soreness felt after exercise, called delayed onset muscle soreness (DOMS). It is the repair of these micro-traumas that results in muscle growth. Normally, this soreness becomes most apparent a day or two after a workout. However, as muscles become adapted to the exercises, soreness tends to decrease.[22]
Change things up. After six or more weeks of consistent strength training, which is about the amount of time it takes to start seeing improvement in your body, you can change your routine to make it more difficult. Lifting the same weights for the same exercises every week will keep your body in the same place. You can modify weights or repetitions, choose different exercises, or change the order in which you do them. You only have to make one change at a time to make a difference, although more is often better. 

Train to muscular fatigue. Many people approach an exercise with a preconceived notion of the exact number of repetitions they will do for each set. (Ten seems to be a popular choice.) These misguided souls are training inefficiently and will never reach their full potential. When performing an exercise, your goal is not a certain number of repetitions. Do not start your set saying, "I'm going to do X number of reps." Depending on the muscle group and your particular athletic objectives, you will probably want to stay within a certain range of repetitions. However, your goal is to fatigue the muscle by performing each exercise (with good form) until you no longer can.
BMR can also be estimated simply by multiplying body weight by 10-11 calories per pound or 22-24 kilocalories per kilogram. So, someone weighing 150 pounds has a BMR close to 1,500-1,650 calories per day. If you're pregnant, add 300 calories to your estimated calorie needs (don't take "eating for two" literally!). If you're breastfeeding, add 500 calories.
Weight training and bodybuilding nutrition are sciences like anything else. There's biology and biochemistry and physiology, with rules and a base of evidence. Selling supplements, most of which are not needed, has become such a huge business in the commercial weight training and bodybuilding industry that it is almost impossible to know if you are getting an objective evaluation of a bodybuilding diet.
"Making strategic changes to your workouts keeps plateauing at bay," agrees Grenade's Vinny Russo. "Once you get comfortable, you tend to stay there. This limits your physical potential, because you're no longer progressing. Get out of that comfort zone and push your limits. Once you become accustomed to that style of training, manipulate another variable to keep making it a challenge!"
Major variants: incline ~ (more emphasis on the upper pectorals), decline ~ (more emphasis on the lower pectorals), narrow grip ~ (more emphasis on the triceps), push-up (face down using the body weight), neck press (with the bar over the neck, to isolate the pectorals), vertical dips (using parallel dip bars) or horizontal dips (using two benches with arms on the near bench and feet on the far bench, and dropping the buttocks to the floor and pushing back up.)
For people struggling to really bulk up or put on muscle mass, consuming sources of rich and healthy fats regularly is the key. People who shy away from fat consumption on fear of putting on weight need to know that fat consumption is good for our metabolism, and fat adds mass which can be converted into muscle with regular and intense workouts. Also, diets such as the ketogenic diet involve healthy usage of fats in for weight loss and muscle gain. Healthy fats are a muscle gainer and must be consumed frequently so as to provide the calories and the bulk needed for our body to break down.
Ever since Arnold Schwarzenegger famously (and colorfully) stated the intense joy of achieving a great pump, bodybuilders have sought it like the holy grail in their training. But make no mistake: The pump is a result of higher-rep training, especially when combined with advanced training techniques that thoroughly exhaust a muscle. That's best left for the end of your workout. The fact is, you don't want to use that style of training to start your body-part training.

You should also have everything you need for simple workouts. Especially if you plan to hit the gym nearly every day, it's a good idea to have some equipment for those rainy days when leaving the house isn't an option. And let's face it: Buying some basic workout items will make your jump into the fitness world more fun. This might sound trivial, but having clothes you like can influence your desire to train.
Think of your muscles as a piece of gum, if you try to stretch a cold piece of gum it will break, similar to your muscles, but if you warm up prior to stretch its like stretching a piece of chewed gum. You should also be stretching before and after cardio, as stated above it enables blood to flood your worked muscles to improve healing and the most important reason is to
The Upper Body B workout starts with pull-ups. Use an overhand grip. If you are unable to do pull-ups, you can do lat pull-downs or some form of assisted pull-up in its place (still using an overhand grip). It’s fine. However, you should make it your eventual goal to be able to do pull-ups and actually work towards eventually doing them here. These are still to be done in front of your head… never behind the neck. Also, if you are someone who can already do 3 sets of 6-8 pull ups, then you need to add weight. Search around online for what’s called a “pull-up belt” (also called a “dip belt”) and buy one. It will allow you to add additional weight to body weight exercises like pull-ups and dips. It’s one of the only training products I fully recommend, and when your own body weight becomes too easy for you, it’s a requirement for progressive overload to take place.
Take time to rest. To give your muscles time to recover, rest one full day between exercising each specific muscle group. You might choose to work the major muscle groups at a single session two or three times a week, or plan daily sessions for specific muscle groups. For example, on Monday work your arms and shoulders, on Tuesday work your legs, and so on.
In step 3, cut back your energy intake by the 15 percent you added previously. Because you're now not the lean guy you once were, you may have to eventually eat slightly more to maintain that extra muscle, but that comes later. Bodybuilders do this to prepare themselves for competition: They put on muscle and some fat by eating, then they strip off the fat, leaving the muscle to show through. It’s called "cutting."
Many men who are on the path of building a better body ignore cardio or look at a cardio as purely assistance on a cut. Huge mistake. Cardio training is training of cardio vascular system. Goes perfectly into longevity mentioned above. Just check main causes of male mortality in your country and see which position cardio-vascular diseases take. Might as well hit that treadmill in order to enjoy your perfectly sculptured body for longer, gentlemen.
Without any goals why would you even bother going to the gym? You need something to motivate you, something to aim for, otherwise you may spend a lot of time and effort in the gym for nothing. Having goals can determine what kind of routine you choose, what type of diet you follow, and ultimately is a great way to keep yourself focused. Many common goals include fat loss, weight loss, increase of size, increase of strength, etc.
Site enhancement oil, often called "santol" or "synthol" (no relation to the Synthol mouthwash brand), refers to oils injected into muscles to increase the size or change the shape. Some bodybuilders, particularly at the professional level, inject their muscles with such mixtures to mimic the appearance of developed muscle where it may otherwise be disproportionate or lagging.[54] This is known as "fluffing".[55][56] Synthol is 85% oil, 7.5% lidocaine, and 7.5% alcohol.[55] It is not restricted, and many brands are available on the Internet.[57] The use of injected oil to enhance muscle appearance is common among bodybuilders,[58][59] despite the fact that synthol can cause pulmonary embolisms, nerve damage, infections, sclerosing lipogranuloma,[60] stroke,[55] and the formation of oil-filled granulomas, cysts or ulcers in the muscle.[59][61][62] Rare cases might require surgical intervention to avoid further damage to the muscle and/or to prevent loss of life.[63]
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